Vuyo Letlapa began his soccer career in the South African lower leagues, emerging as a promising left‑back with Jomo Cosmos in the ABC Motsepe League. His attacking traits from defense, combined with strong work rate and versatility, helped him stand out at youth and senior levels before making the step up to professional football. iDiskitimes+1

In July 2024, Letlapa joined Sekhukhune United in the South African Premier Division, often referred to by fans as Babina Noko. He impressed during his debut top‑flight season, featuring in 27 matches across competitions and providing several assists, solidifying his reputation as a rising star in the league. Farpost

Letlapa’s strong form at club level earned him his first senior South Africa national team call‑up in March 2025 for the 2026 FIFA World Cup qualifiers. His performances domestically also drew transfer interest from overseas clubs—including reported approaches from Austria Vienna and OGC Nice—although Sekhukhune United elected to retain him to aid his continued development. iDiskitimes+2Farpost+2

At international level, Letlapa has represented South Africa in qualifiers and regional competitions such as the COSAFA Cup, further showing his potential on bigger stages.